Strong designAsian J Urol 2026
The aim of this study was to provide information on the factors associated with mortality in conservative management of kidney stone disease (KSD). Secondary aims were to identify important risk factors and highlight key learning points to reduce mortality from conservatively managed KSD. A systematic literature review…
Dassanayake SN, Harrison NL, Geraghty R et al. · PMID 42604105
Strong designWorld J Urol 2026
Patients with lower pole stones (LPS) present a significant challenge for urologists because of the increased likelihood of residual fragments and recurrence following extracorporeal shockwave lithotripsy (ESWL) and retrograde intrarenal surgery (RIRS). Although percussion, diuresis, and inversion (PDI) therapy has dem…
Gimenez LGS, Marchini GS, Torricelli FCM et al. · PMID 42606615
Strong designCancers (Basel) 2026
Background: Upper tract urothelial carcinoma (UTUC) is a rare malignancy representing approximately 5-10% of all urothelial cancers. Key risk factors include smoking, chemical exposures, selected metabolic conditions, and hereditary cancer syndromes. This narrative review summarises current knowledge on UTUC molecular …
Zawadzki D, Libergal N, Nowak J et al. · PMID 42588616
Urolithiasis 2026
Kidney stone disease is a prevalent urological condition with rising incidence and high recurrence rates, yet effective pharmacological interventions remain lacking [1] Prostaglandin E₂ (PGE₂) and its receptor EP3 have been implicated in inflammatory kidney injury [1-3], but their role in nephrolithiasis is unclear. Th…
Leng J, Li Y, Tang X et al. · PMID 42599300
Asian J Urol 2026
This review aims to comprehensively evaluate the mechanisms of action of sodium-glucose cotransporter 2 inhibitors (SGLT2is), with a specific focus on their relevance to urological practice, including both potential benefits and risks. A systematic literature search was conducted in February 2025 using PubMed, Embase, …
Talyshinskii A, Gauhar V, Kar Kei Yuen S et al. · PMID 42604279
Biochem Pharmacol 2026
Calcium oxalate (CaOx) kidney stone disease is common and highly recurrent, but the upstream mechanisms that predispose renal tubules to crystal deposition remain unclear. This study investigated whether disruption of environmental light-dark cycles promotes CaOx crystal deposition through NR1D1-dependent metabolic and…
Gao S, Huang K, Wan S et al. · PMID 42600948
J Wildl Dis 2026
Nephrolithiasis in cetaceans has been documented primarily in managed populations of bottlenose dolphins (Tursiops truncatus) with few described cases of nephroliths and vaginoliths in free-ranging cetacean species. Between 2006 and 2023, renal and/or vaginal calculi were identified on necropsy in 16 cetaceans that str…
Hunter NE, Niemeyer ME, Lulich J et al. · PMID 42603712
Asian J Urol 2026
Kidney stone disease is a relapsing disease and preventive measures are therefore of great importance. A cornerstone for adequate treatment and prevention of kidney stone recurrence is stone analysis. This pilot study aimed to evaluate whether time and different ex vivo environments, such as liquid media or light expos…
Henderickx MMEL, Stoots SJM, van den Elzen RM et al. · PMID 42604256
Cureus 2026
Urolithiasis is a common urological disorder with a high recurrence rate and increasing global burden. Retrograde intrarenal surgery (RIRS) is an established minimally invasive treatment for renal and upper ureteric calculi. The ureteral access sheath (UAS) facilitates repeated access, improves irrigation, reduces intr…
Patil SB, Patil S, Kundargi VS et al. · PMID 42577927
BJU Int 2026
To describe contemporary trends in kidney stone disease (KSD)-related inpatient episodes, procedures, and costs in England and Scotland, with emphasis on post-coronavirus disease 2019 (COVID-19) service recovery, socioeconomic variation in Scotland, comparison with other urological procedures, and 10-year healthcare de…
Lovegrove CE, Geraghty R, Ahmad I et al. · PMID 42581823
Front Med (Lausanne) 2026
Patients with kidney disease have a high incidence of kidney stones, yet the specific mechanisms remain elusive. The purpose of this study was to explore the connection between urinary lithogenic factors and renal function. We retrospectively analyzed 150 patients with kidney disease -associated nephrolithiasis and 84 …
Dong Q, Xu H, Xu P et al. · PMID 42609264
World J Urol 2026
To evaluate the presence of Randall's plaque and its severity in patients with nephrolithiasis and to correlate it with demographic characteristics, metabolic parameters and stone analysis. Consecutive patients undergoing retrograde intrarenal surgery (RIRS) who met study criteria were prospectively enrolled. Demograph…
Chitrakar A, Shrestha A, Adhikari B et al. · PMID 42579014